To examine the cost-effectiveness and safety of generic versus branded Nexium (esomeprazole) in the treatment of acute acid reflux (AER) in patients with chronic idiopathic reflux. Methods
A generic approach to assessing cost was used to compare the cost-effectiveness of Nexium (esomeprazole) versus Nexium (esomeprazole) in patients with AER in the treatment of chronic idiopathic reflux (CIDR) using the fixed-dose combination of Nexium (esomeprazole) and a generic alternative (Nexium) based on the American Heart Association (AHA) guidelines [1]. The analysis included patients who were admitted to the University of Pennsylvania, and patients who had AER and a generic alternative (Nexium) that could be included in the analysis (Nexium and generic alternative were excluded). The data were pooled according to the primary and secondary endpoints. The incremental cost-effectiveness ratio (ICER) for the generic approach was calculated by combining Nexium and generic alternative costs. Results
The cost-effectiveness ratio for generic Nexium versus generic alternative for the treatment of acute acid reflux in patients with chronic idiopathic reflux showed a cost-effectiveness threshold of $20,000 (ICER=1) and a cost-effectiveness threshold of $50,000 (ICER=2) in patients with CIDR. The incremental cost-effectiveness ratio (ICER) for the generic approach for Nexium and generic alternative treatment of acute acid reflux in patients with CIDR was estimated to be $3,800 (ICER=1). The mean cost per 1,000 patients with a generic alternative was $6,400. The mean cost per 1,000 patients treated with generic Nexium versus generic alternative treatment was $15,600 for Nexium. The mean cost per 1,000 patients with generic Nexium versus generic alternative treatment was $15,500. The mean cost per 1,000 patients treated with generic Nexium versus generic alternative treatment was $13,600 for Nexium. Conclusion
The incremental cost-effectiveness ratio (ICER) for the generic approach was estimated to be $3,800 (ICER=1). The incremental cost-effectiveness ratio (ICER) for the generic approach for the treatment of acute acid reflux in patients with CIDR was estimated to be $3,800 (ICER=2).
The incremental cost-effectiveness ratio (ICER) for the generic approach was estimated to be $3,800 (ICER=1) and a cost-effectiveness threshold of $50,000 (ICER=2).
Efficacy and safety of generic Nexium versus generic alternative in acute acid reflux have been assessed by the European Medicines Agency (EMA), the European Association for the Study of Acid Reflux (EASA), and the British Medical Association (BMA) (1). The EASA considers the efficacy and safety of generic Nexium compared with generic alternatives in acute acid reflux in adults with chronic idiopathic reflux (AER). The EASA recommends that the generic alternative be considered in the treatment of patients with AER in adults with chronic idiopathic reflux (CIDR) to ensure the best treatment outcomes (1).
Q. How soon will the new NEXIUM 20mg/Gyno tablets come out?
A. The first NEXIUM 20mg/Gyno tablets will be ready for launch in the fourth quarter of this year. In the meantime, you can check out NEXIUM 20mg/Gyno for more information about how this new medication may help you and your patients.
The NEXIUM 20mg/Gyno NDT formulation is used for the treatment of benign prostatic hyperplasia (BPH) in women. NEXIUM 20mg/Gyno tablets are the active ingredient of the NEXIUM tablets. These tablets contain 20 mg of Gyno and 20 mg of Nexium.
NEXIUM 20mg/Gyno 20mg tablets are indicated for the treatment of gastroesophageal reflux disease (GERD) in patients with moderate to severe heartburn. NEXIUM 20mg/Gyno tablets are indicated for the treatment of GERD in the post-marketing period after the end of a course of proton pump inhibitor (PPI) treatment.
NEXIUM 20mg/Gyno 20mg tablets are manufactured by Eli Lilly. The patents covering the manufacturing processes for these NEXIUM tablets have expired. This means that NexIUM 20mg/Gyno tablets are now available for purchase and supply to the market.
NEXIUM 20mg/Gyno 20mg tablets are available at a cost-effective price to the general public. This is because these tablets are produced at a low cost and do not have high drug quality. The high drug quality of NEXIUM tablets means that the prices may be lower than those available in the retail retail stores.
NEXIUM 20mg/Gyno 20mg tablets are available in the form of oral solution, film coated tablet or chewable tablets. The NEXIUM 20mg/Gyno tablets are available in the form of film coated tablets with no coating, soft gel and capsule. The tablets are available in blister pack form. The NEXIUM 20mg/Gyno tablets are available in the form of tablets and capsules. The chewable tablets are available in the form of soft gel and capsule.
NEXIUM 20mg/Gyno 20mg tablets are the active ingredients in the NEXIUM tablets which contain the active ingredient Gyno. These are indicated for the treatment of gastroesophageal reflux disease (GERD) in patients with moderate to severe heartburn.
NEXIUM 20mg/Gyno 20mg tablets are also indicated for the symptomatic treatment of GERD. This is because these tablets contain Nexium. Patients should take the tablets for the shortest possible time to allow for their healing time.
NEXIUM 20mg/Gyno 20mg tablets are also indicated for the symptomatic treatment of acute dyspepsia (abnormal stomach emptying). This is an allergic reaction to Nexium or the ingredients of the NEXIUM tablets.
NEXIUM 20mg/Gyno 20mg tablets are also indicated for the treatment of acid regurgitation. This is when acid in the stomach empties, so that the lining of the stomach does not get upset.
NEXIUM 20mg/Gyno 20mg tablets are also indicated for the symptomatic treatment of dyspepsia. This is when dyspepsia is caused by a virus. The symptoms of dyspepsia may include a sour or bitter taste in the mouth.
NEXIUM 20mg/Gyno 20mg tablets are also indicated for the treatment of erosive reflux esophagitis. This is when there is an inflammation of the esophagus.
NEXIUM 20mg/Gyno 20mg tablets are also indicated for the symptomatic treatment of gastroesophageal reflux disease (GERD). This is when there is an ulcer in the stomach causing food to flow back into the stomach.
Esomeprazole is used to treat certain conditions such as esophagitis and gastritis, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome. It works by preventing the breakdown of gastric acid, which allows the stomach to heal, and helps prevent further damage to the lining of the stomach. Esomeprazole is also used to treat Zollinger-Ellison syndrome.
If you have heartburn, stomach ulcers, or acid reflux disease, talk to your doctor about whether or not you should take esomeprazole. You may need to take esomeprazole for longer periods of time to help prevent recurrence.
To relieve symptoms, take esomeprazole as a capsule. If you are unable to swallow the capsule, esomeprazole capsules can be crushed and broken. You can also take a liquid capsule to be taken by mouth.
What is esomeprazole?Esomeprazole is a prescription medicine used to treat certain conditions, such as gastroesophageal reflux disease (GERD), stomach ulcers, and Zollinger-Ellison syndrome.
Esomeprazole is available under the following brand names:
Other brand namesNexium, Esomeprazole, Nexium®
Generic nameNexium, Esomeprazole
Brand namesEsomeprazole (Nexium), Esomeprazole (Nexium®), Nexium® (Nexium™), Esomeprazole XR, Nexium, and Esomeprazole XR+ are also available.
How is esomeprazole taken?The usual dosage and frequency of taking esomeprazole is one tablet taken once daily, taken with or without food, with or without water. Esomeprazole is usually taken with a glass of water. The dose is usually increased with food to ensure a steady amount of esomeprazole is consumed.
Common side effects of esomeprazole
Who should not take esomeprazole?Esomeprazole should only be used by individuals who are experiencing:
Esomeprazole is not recommended for children under 6 years of age, and should not be used for children below 14 years of age. Use of Esomeprazole for children under 14 years of age is not recommended.
What should I tell my healthcare provider before taking esomeprazole?Your healthcare provider should tell you about any history of hypersensitivity reactions to esomeprazole or to other proton pump inhibitor medicines, including products including Nexium and Nexium XR, esomeprazole capsules, esomeprazole magnesium, and Esomeprazole tablets. You should also tell your healthcare provider about any prior medical conditions, especially heart problems, kidney problems, or liver problems. In addition, tell your healthcare provider about any prior medical conditions, especially liver or kidney problems. Esomeprazole may interact with other medicines, including blood thinners, and should be used under medical supervision.
What is Reflux?
Reflux is the backflow of acid from the stomach into the gullet (“foodpipe”) which may become inflamed and painful. This may cause you symptoms such as a painful sensation in the chest rising up to your throat (heartburn) and a sour taste in the mouth (acid regurgitation).
Do I get instant relief from taking a Nexium tablet?
Nexium Control is not meant to bring immediate relief. You may need to take the tablets for 2-3 days in a row before you feel better. You must talk to a doctor if you do not feel better or if you feel worse after 14 days.
How much to take• The recommended dose is one tablet a day. • Do not take more than this recommended dose of one tablet (20 mg) a day, even if you don’t feel an improvement immediately. • You may need to take the tablets for 2 or 3 days in a row before your reflux symptoms (for example, heartburn and acid regurgitation) get better. • The treatment length is up to 14 days. • When your reflux symptoms have completely gone you should stop taking this medicine. • If your reflux symptoms get worse or do not improve after taking this medicine for 14 days in a row, you should consult a doctor. If you have persistent or longstanding, frequently recurring symptoms even after treatment with this medicine, you should contact your doctor. Taking this medicine • You can take your tablet at any time of the day either with food or on an empty stomach. • Swallow your tablet whole with half a glass of water. Do not chew or crush the tablet. This is because the tablet contains coated pellets, which stop the medicine from being broken down by the acid in your stomach. It is important not to damage the pellets.
Alternative method of taking this medicine• Put the tablet in a glass of still (non-fizzy) water. Do not use any other liquids. • Stir until the tablet breaks up (the mixture will not be clear) then drink the mixture straight away or within 30 minutes. Always stir the mixture just before drinking it. • To make sure that you have drunk all of the medicine, rinse the glass very well with half a glass of water and drink it. The solid pieces contain the medicine – do not chew or crush them
Please read the patient information leaflet above to get more information as to side effects, precautions of use etc.
Active Ingredients:
Each gastro-resistant tablet contains 20 mg esomeprazole (as magnesium trihydrate)
List of Excipients:
Glycerol monostearate 40-55 HydroxypropylcelluloseHypromellose 2910 (6 mPa-s) Reddish-brown iron oxide (E-172) Yellow iron oxide (E-172)Magnesium stearate Methacrylic acid ethylacrylate copolymer (1: 1) dispersion 30 per cent Cellulose microcrystallineSynthetic Paraffin Macrogol 6000Polysorbate 80 Crospovidone (Type A) Sodium stearyl fumarateSugar spheres (sucrose and maize starch), Talc, Titanium dioxide (E-171) Triethyl citrate
Add 1 tablet to original pouchNexium Control should not be used if you are pregnant or breastfeeding. Take all medicines listed in the IMPORTANTShare section before taking this medicine. You should not use Nexium if you are allergic to esomeprazole or any other similar medicines. This medicine contains hidden fentanyl and should not be used if you have the following with you:
• kidney disease. Nexium may increase the risk of kidney damage. In these you may need to take extra doses of Nexium. This may happen early in your doctor’s practice or only once. These may need to be taken with your normal medicine. These needs must be balanced by monitoring right away.
• severe heart failure. Nexium may help to reduced the risk of heart attack in patients with a recent history of heart failure. These should be checked and managed before taking this medicine. • liver problems. Nexium may affect the results of the blood test for liver function.
• Benign tumours of the prostate or prostate lisase is recommended.
Stade de France Pharmacy